长春地区儿童和献血员人巨细胞病毒感染的调查

A SURVEY ON HUMAN CYTOMEGAL-OVIRUS INFECTION IN CHILDREN ANDBLOOD-DONORS IN CHANGCHUN

用核酸分子杂交技术，对长春地区１２９名献血员、３００名儿童人巨细胞病毒感染状况和输血后获得人巨细胞病毒感染的危险性进行了研究。结果表明，长春地区献血员人巨细胞病毒的带毒率为１７．１％；儿重带毒率为１９．８％，儿童尿排毒率为１５．６％。在儿童中，其带毒率在年龄上无显著差别，１０岁以后，女性高于男性；尿排毒率与性别无关，但１～５岁组明显高于其他年龄组。儿童输血后，获得人巨细胞病毒的感染危险性为５．３。提示输血在人巨细胞病毒传播中占有重要地位；在儿童中，５岁以下为重点监测对象。

uman cytomegalovirus (HCMV) infection wasstudied in 129 blood donors and children of Changchunarea by using nucleic acid hybridization method. The re-sults showed that HCMV carrier rate was 17. 1% inblcod-donors and 19. 8% in children. In children, thedifferences in HCMV-DNA positive rate in blood werenot statistically significant among different age groups,but it was higher in girls than in boys older than 10years. The rate of HCMV shedding in urine was15. 6% , significantly higher in 1～5 years old childrenthan the others. The risk of post-transfusion HCMV in-fection in children was 5. 3 times of that of the controlgroup. The results suggest that blcod transfusion is animportant route of transmission of HCMV infection.Children under 5-years of age should be the main popu-lation monitored for HCMV infection.