摘要
采用间接过氧化物酶免疫法(IPA),检测99例宫颈病变患者血清中抗沙眼衣原体(CT)抗体,同时采用共有引物聚合酶链反应(PCR)技术,检测其中40例CT阴性或CT阳性患者石蜡包埋宫颈组织中人乳头状瘤病毒(HPV)。结果:(1)宫颈癌组CT感染率为61.5%,宫颈非典型增生组为83.3%,宫颈糜烂组为39.5%(P<0.01)。(2)CT阳性病例,阴道镜下观察白色上皮发生率为28.6%,CT阴性病例为6.5%(P<0.05)。CT、H_1,V双重感染的非典型增生病例发生白色上皮者高于CT单项感染。(3)CT阳性的宫颈癌、非典型增生病例中,HPV感染率为60%,明显高于CT阴性的宫颈癌、非典型增生病例的10%(P<0.01)。提示:CT、HPV在宫颈癌的发生中,具有协同作用。
bjective To reveal the relationship between cervical carcinoma,dysplasia and infections of hu-man papillomavirus(HPV)and/or chlamydia trachomatis(CT)。Methods Indirect immunoperoxidase assay(IPA)was used in 99 patients with cervical lesions to test the specific antibody to CT in serum. At the same time,HPV in biopsies was determined from 40 patients with or without CT infection by using polymerase chain reaction(PCR).Results(1)CT infection was found in a significantly greater proportion in women suffering from cervical carcinoma (61.5%)and dysplasia (83.3%)than in those of the control group(39.5%)(P<0. 01).(2)Under colposcopy, the incidence of white epithelium in patients suffering from dys-plasia was 28.6%(12/42) in the CT positive group,while in the CT negative group the incidence was 6.5%(2/31).The incidence of white epithelium in patients with both CT and HPV infections was higher than that in patients with CT infection alone(3)In CT positive group, the incidence of HPV in patients suffering from cervical cancer and from dysplasia(60%)was much higher than that in the CT negative group(10%)。Conclusions CT and HPV- infections play a synergetic role in the etiology of cervical cancer.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
1995年第9期547-549,共3页
Chinese Journal of Obstetrics and Gynecology
关键词
乳头状瘤病毒
沙眼衣原体
子宫颈肿瘤
癌前病变
Papillomaviruses Chlamydia trachomatis Cervix neoplasms Precancerous condition