摘要
30例择期开胸患者随机分为两组,K组(酮咯酸30mg)15例,P组(哌替陡50mg)15例。术后当晚刀口疼痛时肌注给药。应用 VAS法测痛,K组镇痛优良率 73, 7%,P组镇痛优良率 80. 0%,经 X2检验无统计学意义(P>0.05)。用药前和用药后1、4、7小时心率(HR)、血压(SBP/DBP)变化,两组内和组间比较均无显著性差异(P>0.05)。用药前和用药后1、7小时呼吸频率(RR)和动脉血气(ABG)变化,两组内和组间比较亦无显著性差异(P>0.05)、用药期间未发现明显的不良反应。结果表明,酮咯酸用于胸科术后镇痛,疗效满意,对循环和呼吸功能影响轻微,巨无呼吸抑制之顾虑。//
The postoperative analgesia with intramuscular ketorolac 30 mg (n= 15 ) or pethidine 50 mg (n= 15 ) was observed comparatively in a single-blind random study. The patients after thoracotomy who requested analgesia were allocated randomly to receive ketorolac 30mg or pethidine 50 mg intramuscularly. Analgesia was assessed according to VAS (visual analogue scale )and a four grade verbal scale,with monitoring the heart rate,blood pressure,respira tory frequency and arterial blood gas before administration, 1,4 and 7 hours after administration respectively. There were no significant differences in VAS and the rate of satisfactory analgesia between two groups (X2 analysis P> 0. 05) and circulatory and respiratory function kept stable. The study showed that the analgesic effect of ketorolac 30 mg was satisfactory and the side effects on the circulatory and respiratory system were slight.
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
1995年第7期307-308,共2页
Chinese Journal of Anesthesiology
关键词
术后镇痛
酮咯酸
哌替啶
药理
Postoperative analgesia Ketorolac Pethidine