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川芎嗪对肝缺血再灌注损伤防护作用的实验研究 被引量:21

AN EXPERIMENTAL STUDY OF THE ROLE OF TETRAMATHYPYRAINE IN ISCHEMIC REPERFUSION-INDUCED LIVER INJURY
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摘要 采用大鼠肝缺血再灌注损伤模型,观察了川芎嗪对肝缺血再灌注损伤的防护作用。结果提示:川芎嗪可显著减少血清转氨酶、LDH的溢出;减轻肝缺血再灌注后肝细胞病理性损伤;明显降低肝组织LPO、TXB2的升高;维持缺血及再灌注期SOD活性。川芎嗪通过抑制肝缺血再灌注时氧自由基产生,提高组织抗氧化能力,维持W/K平衡。 he protective effects of tetramethypyrazine (TMP)on ischemia-reperfusion liver injurywere studied by using a l20-minute warm ischemia-reperfusion rat model.serum enzymelevels and the amount of hepatic lipid peroxides (LPO) and thromboxaneB2(TXB2)weresignificantly increased during liver ischemia-reperfusion; the increment was significantlyinhibited by TMP treatment. The hepatic superoxide dismutase (SOD)activity graduallydecreased being higher in the TMP-treated than in the untreated groups. Liver pathology bylight microscopy was much less pronounced in the TMP group. These results suggested thatTMP could protect the liver against ischemia-reperfusion injury.
出处 《中华消化杂志》 CAS CSCD 北大核心 1995年第3期139-141,共3页 Chinese Journal of Digestion
关键词 川芎嗪 肝缺血再灌注 氧自由基 血栓素 前列环素 TMP Liver ischemia-reperfusion Liver injury Oxygen free radic-al Thromboxane Prostacyclin.
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参考文献4

  • 1许顺滨,中国应用生理学杂志,1989年,5卷,26页
  • 2赵根尚,中西医结合杂志,1988年,8卷,284页
  • 3李建武,第二军医大学学报,1987年,8卷,371页
  • 4吴余升,中西医结合杂志,1985年,3卷,169页

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