期刊文献+

Ⅰ、Ⅳ型胶原及板层素在肝纤维化大鼠肝窦周围的变化 被引量:42

ALTERATIONS OF COLLAGEN TYPEI, ⅣAND LAMININ IN PERISINUSOIDS OF FIBROTIC RAT LIVER
原文传递
导出
摘要 运用免疫组化方法检测大鼠肝脏的Ⅰ、Ⅳ型胶原及板层素(LM),发现三者在正常大鼠肝窦周围均有少量存在。在经CCl4刺激后造成肝纤维化大鼠的肝脏,第6周造模组肝窦周围Ⅰ型胶原与正常组相似,Ⅳ型胶原明显减少,LM增多;第11周造模组大鼠肝窦周围的Ⅰ型胶原仍无增多,Ⅳ型胶原进一步减少,LM则比第6周末明显降低。提示肝纤维化时,大鼠肝脏内皮细胞和肝细胞之间大量的功能性基底膜遭受破坏,但因连续性基底膜的形成受到干扰,肝窦毛细血管化程度不很严重,此可能是CCl4肝纤维化大鼠有自愈倾向的原因之一。 Using immunohistochemical method, we found that there was a little type I and Ⅳcollagen and laminin(LM) in perisinusoids of normal rat liver In CCl4-induced hepaticfibrosis of rats at the 6th week,the quantity of collagen type Ⅰ in the hepatic perisinusoidswas as about the same as that Of normal rat group, collagen type Ⅳ decreased obviously, andLM elevated. At the 11th week, the quantity of collagen type Ⅰ still did not increase, collagentype Ⅳ decreased continuously, and LM was far less than that of the 6th week group Thesealterations indicated that, in hepatic fibrosis, functional basement membrane was damagedbetween endothelial cells and hepatocytes in rat liver, but capillarization of sinusoids was notmarked because of some disturbances in forming a continuous basement membrane. This maybe one of causes leading to self-resolution of fibrosis induced by CCl4-in rat liver.
出处 《中华消化杂志》 CAS CSCD 北大核心 1995年第3期146-148,共3页 Chinese Journal of Digestion
关键词 肝纤维化 免疫组化 肝窦毛细血管化 Hepatic fibrosis Immunohistochemistry Capillarization of sinusoids.
  • 引文网络
  • 相关文献

参考文献4

  • 1徐列明,中药药理与临床,1993年,9卷,14页
  • 2吴秉毅,国外医学消化系疾病分册,1992年,12卷,66页
  • 3王杰军,中华消化杂志,1992年,12卷,30页
  • 4王宝恩,肝脏病学进展’90,1991年

同被引文献317

引证文献42

二级引证文献306

;
使用帮助 返回顶部