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交联聚磷酸酯的合成及其释药性能研究 被引量:13

Synthesis of Crosslinked Polyphosphates and Drug Release
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摘要 以(i-Bu)_3Al为引发剂研究了2-氢-氧-1,3,2-二氧五环磷酸酯,2-氢-2-氧-1,3,2-二氧六环磷酸酯的开环均聚和共聚合反应,然后经过氯化、水解获得了交联聚磷酸酯材料。以合成的交联聚磷酸酯为药物载体,采用单层骨架片、双层骨架片和夹心片的载药方式,对抗肿瘤药物5-氟尿嘧啶进行了控制释放,获得了较好的释药效果。 Ring-opening polymerizations of 2-hydro-2-oxo-3,2-dioxa-phospholan and/or2-hydro-2-oxo-1,3,2-dioxaphosphorinane were studied using(i-Bu3)Al as initiator. After chlorination and hydrolysis, crosslinked polymers were obtained.The in vitro release of 5-fluorouracil from its single-matrix pellets,double-layered pellets and sandwich pellet with the crosslinked polyphosphates as drug carriers were carried out in phosphate buffer solution(pH 7.4)at 37℃. Sustained release from the sandwich pellet was more controlled than that from the single-matrix pellets and double-layered pellets.
机构地区 北京大学化学系
出处 《高等学校化学学报》 SCIE EI CAS CSCD 北大核心 1995年第10期1633-1636,共4页 Chemical Journal of Chinese Universities
基金 国家自然科学基金
关键词 磷酸酯 氟尿嘧啶 释药性能 Crosslinked polyphosphate,5-Fluorouracil,Drug release
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