更昔洛韦治疗小儿传染性单核细胞增多症的临床疗效观察

Clinical observation of the effect of ganciclovir on the infectious mononucleosis in children

目的观察更昔洛韦注射液治疗小儿传染性单核细胞增多症的临床疗效.方法将62例传染性单核细胞增多症患儿随机分为治疗组32例和对照组30例,分别静脉给予更昔洛韦10mg/(kg*d)和利巴韦林10～15mg/(kg*d),观察临床体征的变化进行分析.结果:治疗组临床症状及体征均较对照组消失早(P＜0.01),治疗组总有效率91.7%,对照组总有效率59.4%(P＜0.01).结论更昔洛韦注射液治疗小儿传染性单核细胞增多症疗程短、见效快、无副作用.

Objective： To observe the curative effect of ganciclovir on children with infectious mononucleosis （IM） . Methods： Sixty-two patients with IM were divided into two groups randomly. The treatment group （ 32 patients） were treated with ganciclovir intravenously （ 10 mg· kg^-1· d^-1 ）, and the control group were treated with ribavii-in intravenously （10-15 mg·kg^-1·d^-1 ）. In the process of treatment, the change of symptoms and signs were observed every day. Resuits：The clinical symptoms and signs of the patients in the treatment group disappeared earlier than those in the control group （ P 〈0.01）. The total effective rate was 91.7% in the treatment group and 59.4% in the control group （ P 〈 0.01）. Conclusion： Ganeiclovir can shorten the treatment period and raise the curative rate without side effect in children with IM.