摘要
目的:研究伴胸腺异常重症肌无力(MG)的临床特点。方法:回顾性分析1990-2002年诊治的伴胸腺异常21例MG,病例资料并与同期无胸腺异常59例MG对比。结果:胸腺异常组男女比例为1:0.91,胸腺正常组男女比例为:1:2.11,按改良Osserman临床分型胸腺异常组临床多表现为Ⅱa、Ⅱb型,胸腺正常组多表现为Ⅰ、Ⅱa,胸腺异常以胸腺瘤和恶性胸腺瘤为主。胸腺异常组危象发生率23.3%,死亡率40%,胸腺正常组危象发生率13.6%,死亡率12.5%。结论:胸腺异常组男性患者明显增加,发病年龄以30-49岁为主。伴胸腺瘤MG临床症状重,胸腺瘤是MG危象的一个重要危险因素。
Objective:To explore the clinical features of myasthenia gravis(MG) with Abnormal thymus gland. Methods:Retrospective study was done on 21 MG patients with Abnormal thymus gland who were diagnosed and treated from 1990 to 2002 and compared with 59 MG patients with normal thymus gland on the same time. Results= Male to female in MG patients with Abnormal thymus gland was 1:0.91, the ratio of 1:2.11 was MG patients normal thymus gland. According to modified Osserman criteria more patient with abnormal thymus gland were classified in group Ⅱ a, Ⅱ b, more patients normal thymus gland were classified in Ⅰ , Ⅱ a, Abnormal thymus gland were relied mainly on thymoma and serious thymoma. The rate of myasthenia crisis and mortality in patients with Abnormal thymus gland were higher than patients with normal thymus gland. Concu|sions: Males were more than females in patients with Abnormal thymus gland. The age at the onset of the disease was from 30 to 49 years. Clinical symptom in patients with thymoma was serious. Thymoma is an important rist factors in myasthenia crisis of MG.
出处
《脑与神经疾病杂志》
2005年第4期297-298,共2页
Journal of Brain and Nervous Diseases
关键词
重症肌无力
临床研究
胸腺异常
Myasthenica Clinical study Abnormal thymus gland