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左旋门冬酰胺酶引起纤维蛋白原降低9例 被引量:4

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摘要 左旋门冬酰胺酶(L-Asparaginase,L-Asp)是急性淋巴细胞白血病治疗中的重要化疗药物,它明显提高了急性淋巴细胞白血病患者缓解率及长期存活率,随着L-Asp在临床上的广泛应用,时有其相关不良反应的报道[1],如急性胰腺炎、肝脏损害、高血糖、过敏等,但有关对凝血影响的报道不多.本文就我院2004年1~6月应用L-Asp治疗的15例住院患者中遇到的9例(60%)因L-Asp致纤维蛋白原(FIB)降低的病例报道如下:
出处 《药物流行病学杂志》 CAS 2005年第3期185-186,共2页 Chinese Journal of Pharmacoepidemiology
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  • 1S. Sica,L. Pagano,P. Salutari,A. Mario,S. Rutella,G. Leone. Acute parotitis during induction therapy includingl-asparaginase in acute lymphoblastic leukemia[J] 1994,Annals of Hematology(2):91~92
  • 2M. Murakawa,T. Okamura,T. Shibuya,M. Harada,T. Otsuka,Y. Niho. Use of a synthetic protease inhibitor for the treatment ofl-asparaginase-induced acute pancreatitis complicated by disseminated intravascular coagulation[J] 1992,Annals of Hematology(5):249~252

共引文献29

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  • 2孙黎明,支文靖,武万水,唐泓,张蕾,王起风,李苗.COALL-97方案治疗急性淋巴细胞白血病临床及实验室研究[J].实用儿科临床杂志,2005,20(1):10-12. 被引量:4
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