摘要
目的:探讨黄连解毒汤对2型糖尿病大鼠血清抗炎细胞因子水平的影响,分析其改善胰岛素抵抗的作用机理。方法:观察黄连解毒汤对实验性2型糖尿病大鼠治疗前后血糖(FBG)、胰岛素(FINS)、血清白介素-4(IL-4)和白介素-10(IL-10)等指标的影响。结果:给予黄连解毒汤治疗的实验性2型糖尿病大鼠,其血清FBG水平显著低于模型组(P<0.01),FINS和模型组比较无显著差异;IL-4和IL-10水平明显高于模型组(均P<0.01)。结论:黄连解毒汤及其主要有效成分小檗碱具有提高2型糖尿病大鼠血清抗炎细胞因子IL-4和IL-10水平的作用,改善其慢性炎性反应和胰岛素抵抗。
Objective: To explore the effect of Huanglian Jiedu Decoction(HID) on serum anti-inflammatory cytokines IL-4 and IL-10 in experimenta type 2 diabetic rats and its therapeutic mechanism on improving insulin resistance. Method: The effect of HID on fasting blood glucose(FBG), fasting insulin (FINS),interleukin-4 ( IL-4 ) and interleukin-10 ( IL-10 ) in type 2 diabetic rats were observed. Results: Compared with model group, the serum levels of FBG-was obviously decreased (P 〈 0.01 ), the variance of FINS level was not significant,and the anti-inflammatory cytokines IL-4 and IL-10 were significantly increased ( P 〈 0.01 ) in HID group. Conclusion: HID and its main effective component 13erberine could increase the levels of IL-4 and IL-10, and alleviate chronic inflammatory reaction in the diabetic pathogenic mechanism. through which they might improve insulin resistance.
出处
《微循环学杂志》
2005年第3期44-45,49,F0006,F0009,共5页
Chinese Journal of Microcirculation
基金
国家自然科学基金资助课题(30371816)