不完全性缺血心肌的超微结构观察

Ultrastructural Alteration of the lncomplete lschemia of Myocarcium

实验造成不完全性心肌缺血及再灌模型，观察其超微病理改变及磷酸肌酸对心肌的保护作用，电镜观察发现：对照组心肌细胞超微结构元明显变化；缺血组心肌细胞肌原纤维普遍出现收缩小带，并有较多巨大收缩带形成（收缩带性坏死），线粒体肿胀，基质颗粒明显增多增大；而治疗组心肌细胞超微病理改变较轻，提示磷酸肌酸对不完全性缺血及再灌心肌有一定的保护作用．

A model of incomplete ischemia and reperfusion mimic was made, which was similar tothe myocardial infarction in clinic in 8 isolated hearts of Wistar rat.The Ultrastructural altera-tion of the myocardium as well as the protective effect of phosphocreatine were observed.Under TEM, there were markedly ultrastructural alterations in the ischemic group suchas:widespreading small contraction-band and some giant contraction-band(contractionnecrosis )of the myofibrils,swollen mitochondria,increasing and augmenting of thematrical granules,etc.there were some very mild changes in the controlled group.Sophospho-creatine might have a certain protective effect.