摘要
γ－去氢骆驼蓬碱等咔啉类生物碱的辐射防护作用利国威，桑培根，潘国英（中山医科大学肿瘤防治中心广州５１００６０）从新疆产蒺藜科植物骆驼蓬（ＰｅｈａｎｕｍｈａｒｍａｌａＬ．）的种子中分离得到３个化合物，其中γ－去氢骆驼蓬碱（γ－ｈａｒｍｉｎｅ，Ⅰ）为新化...
γ- Harmine(Ⅰ),’
harmine(Ⅱ )and harmaline(Ⅲ )were isolated from PeganumHarmala L.(
Zygophylaceae).Tests were conducted with mice to detect whether γ-
harmine( a newcompound), harmine,harmof(Ⅳ)and harmalol(Ⅴ) are
effective radioprotective compounds againstγ-ray irradiation,
Intraperitoneal injection of the hydrochlorides of the four alkaloids
50～80mg·kg-1×1 in NIH male mice 30～45 minutes before 8.6～9. 7 Gy
whole body 60Co irradiationsignificantly increased the survival
effects(1. 33～2. 61)and 30-day survivai rate in comparison
withcontrol mice.The results indicatethat γ- harmine exhibited
relatively good radioprotective effect.γ-harmine is the first
alkaloid isolated from a plant having ptotective effects against
whole-body lethal irradiation in mice。
出处
《药学学报》
CAS
CSCD
北大核心
1995年第9期715-717,共3页
Acta Pharmaceutica Sinica
