摘要
从绿茶中提取的多酚类化合物,具有很强的抗氧化作用。这种绿茶提取物(GTE)在BALB/3T3细胞转化实验中,可以明显抑制TPA的促癌作用。体内实验表明,GTE可以抑制TPA诱导小鼠耳皮肤水肿,并抑制TPA诱导小鼠皮肤乌氨酸脱羧酶活性增高.次黄嘌呤和黄嘌呤氧化酶反应产生的含氧自由基可以引起IAR20肝细胞SCE增高,而GTE可明显抑制这种自由基对细胞SCE的诱导作用.本文讨论了GTE抑制促癌作用的有关机制.实验结果表明,GTE可能对于某些肿瘤的预防具有应用价值.
Polyphenol components isolated from green tea showed strong antioxidant activity. The green tea extract (GTE) significantly inhibited the promoting effect of TPA in BALB/3T3 cell transformation assays. In in vivo experiments, GTE inhibited edema induced by TPA in mouse ear. The inhibitory effect of GTE on the induction of ornithine decarboxylase activity was also found in mouse skin treated with TPA. GTE decreased the frequency of SCE induced by oxygen radical in IAR 20 liver cells treated with hypo-zanthine and xanthine oxydase.Mechanisms of the antipromoting effect of GTE are discussed. Our experimental results suggest that GTE may have some practical use in cancer prevention.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
1989年第4期259-264,共6页
Acta Academiae Medicinae Sinicae
