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无名质区破坏的Wistar大鼠脑内胆碱乙酰转移酶和生长抑素活性的变化及相互关系 被引量:18

Changes and their correlation in the activities of ChAT and SS in the brain of Wistar rat with substantia innominata damage
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摘要 本研究选用Wistar系雄性大鼠,通过向鼠脑的无名质区注射Ibotenicacid,造成中枢胆碱能系统破坏的动物模型。采用放免方法,测定了无名质区破坏后大鼠不同脑区ChAT活性和SS含量的变化。结果发现:大鼠一侧无名质区破坏后,同侧大脑皮质额叶,顶叶的ChAT活性显著下降,同时同侧额叶、顶叶及海马的SS含量也明显降低。结果提示:中枢胆碱能系统和生长抑素系统有极密切的关系,无名质区破坏后脑内SS含量的下降,可能是伴随着胆碱能系统损伤的继发性改变。推测SS系统可能接受胆碱能系统的传入,参与对学习、记忆的调节。 The ibotenic acid was injected into the substantia innominata of the Wistar rats to make the model of central cholinergic system deficit. The contents of ChAT and SS in different brain regions of the rats were observed by radioimmunoassay.The results showed that the activities of ChAT was markedly decreased at the frontal and parietal lobe in the same hemisphere and the contents of SS was markedly decreased at the frontal,parietal lobe and hippocampus.We suggested that the relationship between the central cholinergic system and SS system was close,and the decrease of SS contents followed the damage of central chlinergic system. We thought that SS system may accept the cholinergic fiber and may be involved in the process of learning and memory regulation.
出处 《中风与神经疾病杂志》 CSCD 北大核心 1995年第3期130-132,共3页 Journal of Apoplexy and Nervous Diseases
关键词 胆碱乙酰 转移酶 生长抑素 基底神经核 无名质 Choline acetyltransforase Somatostatin Substantia innominata Nucleus basalis of meynert.
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