人巨细胞病毒感染对围产儿的影响

The influence of human cytomegalovirus infection on the perinatal infants.

应用酶联免疫吸附测定法(ELISA),检测11119例孕妇静脉血和7643例新生儿脐血以及母儿配成5936对母儿的血清中,巨细胞病毒(HCMV)的特异性抗体 IgG、IgM,了解本市孕妇及围产儿感染情况,并调查 HCMV 感染对围产儿死亡和畸形的影响。结果:孕妇 HCMV-IgG 阳性率为76.94%,HCMV-IgM 阳性率为2%。新生儿脐血 HCMV-IgG 阳性率为50.54%,HCMV-IgM 陌性率为0.92%;配成5936对血清检测中,母体血清 HCMV-IgG 阳性率70.52%,脐血清阳性率51.01%,有72.34%的围产儿被动获得了母亲的 IgG 抗体;母体血清 HCMV-IgM 阳性率为1.79%,脐血 HCMV-IgM 阳性率为0.91%,有50.94%传播给围产儿致营内感染,导致围产儿的病死率为92.59‰、畸形率为7.4%,与其他因素引起的围产儿病死率(28.90‰)、畸形率(1.31‰)有显著差异(P<0.05)。

To determine the condition of HCMV infection and its influence on the mortality and malformation rate of perinatal infants.Design:To apply Enzyme Linked Immunosorbent Assay to detect specific anti- bodies of I gG and I gM in maternal venous blood, the umbilical blood and in the sera of mothers and in- fants.Results ..In comparison with the mortality and malformation rate caused by other factors,the differ- ence betwween them was obvious(P<0.05).Conclu- sion:HCMV infection constitutes a severe threat to perinatal infants