糖耐量低减患者的尿白蛋白排出率观察

A study on the increased urinary albumin excretion in patients with impaired glucose tolerance

测定了７７２例ＩＧＴ患者尿白蛋白排出率（ＵＡＥ），并与７８７例正常对照者作了比较。结果显示ＩＧＴ患者ＵＡＦ和微量白蛋白尿发生率明显高于正常对照组。此外，ＩＧＴ患者的血压、ＢＭＩ、血清Ｃｈ、Ｔｇ、Ｃｒ也明显增高，而ＨＤＬ－Ｃｈ则明显低于正常对照组。ＩＧＴ伴高血压者的ＵＡＥ高于正常血压者。正常血压组中肥胖者的ＵＡＥ高于非肥胖者。多元逐步回归分析显示ＩＧＴ和正常人的ＵＡＥ与ＢＭＩ、ＭＢＰ、服糖后２小时血糖呈正相关，而与ＨＤＬ－Ｃｈ呈负相关。提示ＩＧＴ患者的ＵＡＥ增加，并伴有发生血管病变的多种危险因素。

Urinary albumin excretion (UAE) was measured in 772 cases of impaired glucose tole rance(JGT)and 787 normal controls.The results showed that the UAE and the incidence of microalbuminuria were significantly higher in IGTs than in normal subjects. In addition, BMI, blood pressure,serum levels of Ch, Tg, Cr were markedly higher, while serum HDL-Ch level was lower in IGTs than in normals. The UAE in IGT patients with hypertension was higher than that of IGT patients with normal blood pressure,The UAE in IGT patients with obesity was higher than those without obesity.Multiple regression analysis showed that UAE in IGT and normal subjects had significantly positive correlation with BMI, MBP and 2-h blood glucose, and significantly negative correlation with serum HDL-Ch.It suggested that IGT patients with elevated UAE had more risk factors for cardiovascular diseases.