吗氯贝胺在鼠强迫游泳行为实验中的抗抑郁效应

Antidepressant effect of moclobemide inhrced swimming test in rats and mice

用大鼠和小鼠强迫游泳行为模型观察了吗氯贝胺的抗抑郁效应。大鼠一次给予吗氯贝胺１０－１００ｍｇ·ｋｇ￣（－１）无影响。２４ｈ内３次强化给药使游泳不动时间减少。若每日给药２次。连续１５次则不但效应进一步加强且呈较好的量效关系，同时活动性不增加。小鼠单次或３次强化给予吗氯贝胺对游泳不动时间均无明显影响。每日１次。连续给药２０ｄ，表现出与大鼠同样的良好效应和量效关系。活动性亦无增高。

Effects of moelobemide (Moc)on thebehdvior of mice and rats in the forced swimming test,an animal model predictive for antidepressant activity,were examincd.In micc.acute administration of Moc(30,100 and 300 mg·kg￣(-1) ig once,or 10,30 and 100mg·kg￣(-1)ig, 3 times in 24 h) did not show anv effectson theduration of immobility,while daily treatment(10,30 and 100 mg·kg￣(-1)ig, once a day for 20 d)dose-dependently reduced the immobility time to88%, 71 % and 59%of the controls respectively with-out stlmulation of motor activity. In rats, a single injec-tion of Moc(10,30 and 100 mg·kg￣(-1) ip) showed noeffects.It was observed that the immobility time wassignificantly decreased to 37% and 64%of the con-trols with 30 and 100 mg·kg￣(-1)of Moc administrated3 times in 24 h respectively. In the chronic experiments(ig,twice a day for 15 d), Moc(10, 30 and 100 mg·kg ￣(-1))dose-dependently reduced the duration ofimmobility to 75 %。 65 % and 44% of the controlsrespectively with milder decrease of locomotion in,theopen field.Imipramine(10 mg·kg￣(-1)), as a comparda-tive drug, showed the same resuIts except the resultthat the anti-immobility effect in mice was not poten-tiated by chronic treatment as compared to acute ad-ministration perhaps owing to the strain difference Inconclusion,th ereversible monoamine oxidase Ainhibitor Moc.active in the forced swimming test,but the effects are significant and dose-dependent inthe chronic treatments.