摘要
用溶剂法制备了维甲醚环糊精的包合物,经电镜扫描,差示扫描量热法证实了包合作用的可能性。维甲酸、维甲酸物理混合物、研磨法及溶剂法制备的包合物的溶解度分别为小于0.2,16,104和173μg/ml。用包合物制成的外用霜剂,临床疗效同等浓度的维甲酸霜,但稳定性增加,毒副作用降低。
The inclusion of retinoic acid in β-cyclodextrin was coprecipitation from a solutionof water:isopropanol(1:1 ).This inclusion was identified by scanning electron microscopy anddifferential scanning calorimetry.The aqueous solubility of retinoic acid,which is less than 0.2μg/ml for the pure product,increased to 16μg/ml for physical mixture, 104 μg/ml for grinding,and reached 173μg/ml for coprecipitation.It is more stable and less irritate for the cream of theinclusion.
出处
《中国药学杂志》
CAS
CSCD
北大核心
1995年第8期472-474,共3页
Chinese Pharmaceutical Journal