摘要
目的研究生活方式和药物干预对糖耐量减低(IGT)高危人群糖耐量的影响,为预防提供依据。方法60例IGT高危人群随机分成两组,生活方式干预组和药物(二甲双胍0.25g,3次/d)干预组,随访3个月,观察糖代谢变化情况。结果生活方式干预组和药物干预组的空腹血糖改善(P<0.05),二者间无显著性差异,葡萄糖耐量试验(OGTT)2h血糖无改善(P>0.05)。结论生活方式干预和二甲双胍干预能降低空腹血糖,二者能否降低OGTT2h血糖,延缓IGT高危人群发生IGT,降低IGT的发病率,还需要进一步的临床研究。
Objective To investigate the impact of liiestyte intervention or medicine intervention on the development of glucose tolerance in relatively high-risk populations of IGT, and provide evidence for prevention of IGT. Methods 60 individuals of high-risk populations of IGT were divided into control group、lifestyle intervention group and medicine （Metformin 0.25g, tid） intervention group. They were followed up three months , changes of blood glucose concentration were observed. Results Fast blood glucose were improved in lifestyle intervention group and Mefformin intervention group （P〈0.05）, the levels of blood glucose two hours after OGTT were not improved （P〉0.05）. Conclusion Lifestyle intervention and Metformin intervention might improve fast blood glucose levels. The study should be continued to observe whether lifestyle intervention and Metformin intervention might improve the levels of blood glucose two hours after OGTT and retard the high-risk populations of IGT develop IGT.
出处
《医药论坛杂志》
2005年第15期9-10,13,共3页
Journal of Medical Forum
基金
深圳市科技计划基金项目(200405133)
