人工肝支持系统治疗慢性重症肝炎临床观察

Clinical Observation of Patients with Chronic Severe Hepatitis Treated by Artificial Liver Support System

目的探讨应用人工肝支持系统(ALSS)治疗慢性重症肝炎的疗效及时机。方法采用血浆置换(PE)对68例慢性重症肝炎患者进行治疗,观察治疗前后主要实验室检查指标的变化,并与对照组66例患者比较不同治疗时期的有效率和总有效率。结果ALSS治疗后,血清TBil、PTA、ALT均明显好转,治疗组早、中期好转率分别为93.8%、55.6%,总有效率48.5%,显著高于对照组的44.4%、14.3%和21.2%(P<0.05)。结论ALSS治疗能使慢性重症肝炎相应生化指标好转,对早、中期疗效较好。

Objective To evaluate the efficacy and opportunity of artificial liver support system （ALSS） in patients with chronic severe hepatitis. Methods 68 patients were treated with plasma exchange （PE）. The serum levels of TBil、ALT、PTA、ALB、Cr were measured before and after treatment and the efficacy of ALSS treatment on the different periods of hepatitis was investigated. 66 patients were used as control. Results There were significant differences of TBil、PTA、ALT levels between before and after ALSS therapy. The improvement rates of early and middle period patients in ALSS treatment group were 93.8% and 55.6%, and the total effectiveness rate was 48.5%. Comparing with the former, the results of control group were 44.4%, 14.3% and 21.2%, respectively. There were significant differences between the two groups, respectively （P〈0.05）. Conclusion ALSS treatment can improve the biochemistry of patients suffering from severe hepatitis. It is more suitable to use ALSS in early and middle stage of chronic severe hepatitis.