黄芩清肺口服液制备工艺研究

Study on Preparation Technological Process of Huangqin Qingfei Koufuye

为了确定黄芩清肺口服液的制备工艺,根据处方药味所含成分的性质特点,进行了以下的研究工作苦杏仁提取HCN的工艺研究;黄芩等药材水提正交试验,以黄芩苷作为定量检测指标,优选出黄芩等药材水提的最佳工艺是以12倍量水煎煮2次,每次1小时;乙醇沉淀工艺研究,确定了乙醇沉淀工艺为加入3倍药液体积的80%乙醇;药液澄明度稳定性工艺研究,通过向芳香水中加入聚山梨酯80,对药液进行冷藏处理,调节药液的pH值,从而解决成品的澄清度问题。

Objective： To study the optimum preparation technological process of Huangqin Qingfei Koufuye for mass production.Methods ： The optimum technology of extraction HCN from Semen Armeniacae Amarum was selected by experiments ; The optimum conditions for the extraction process was selected with orthogonal design, and the content of baicalin in the extract as marker was determined. Results： The optimum technology of extraction HCN from Semen Armeniacae Amarum was as follows： crushing to pieces, adding 3 times amount of 37℃ water and soaking overnight, extracting and collecting 1.33 times amount of extract ; the optimum extraction process wasas follows： extracting 2 times, each time adding 12 times amount of water and extracting 1 h. Conclusion： The preparation technological process can be used for mass production.