摘要
目的:研究清肝活血方防治酒精性肝病大鼠肝脏脂质过氧化损伤的影响。方法:采用乙醇、吡唑、玉米油混合液连续灌胃14周,形成酒精性肝病大鼠模型,分为清肝活血方低、高剂量组,以小柴胡冲剂为对照,观察其对肝内脂质过氧化产物的影响。结果:清肝活血方可明显降低升高的ALT、AST、GGT、ALP、LDH,抑制IL1、IL6、TNFα、TGFα的升高;降低血清透明质酸、层粘蛋白水平。结论:清肝活血方对酒精性肝病有明显防治作用,而调节免疫活性因子、抗炎、抗肝纤维化发生可能是其作用机制之一。
Objective: To study ettects ot Qinggan Huoxue decoction (decoction of cleating liver and promoting blood circulation) on alcoholic liver disease (AID) , Methods: rat AID models were induced by mixed liquids of ethanol, pyrazole and corn oil through consecutive gastric infusion in 14 weeks. The Qing gan Huo xue decoction treatment group were :divided into low and digh dosage groups, while positive control group were treated with Xiao Chaihu decoction. The effects were studied as products of liver lipid peroxidition. Results: Experimental study showed the Qingan Huoxue decoction could depress the elevation level of ALT, AST, GGT, ALP and LDH, inhibit the levels of cytokines, decrease serum level of hyaluronic acid and laminin. Conclusion: The Qingan Huoxue decoction could prevent and cure AID markedly, its mechanism might be adjusting immune function, anti-fubrosis, and inhibit inflections, promoting the metabolism of ethanol in liver.
出处
《中西医结合肝病杂志》
CAS
2005年第4期218-220,共3页
Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
基金
上海市启明星跟踪计划资助(No:03Q1410)