芬太尼透皮贴治疗癌痛疗效观察

Study on the Therapeutic Effect of Fentanyl Transdermal System on Cancer Pain

目的:观察芬太尼透皮贴治疗晚期癌痛的镇痛效果及不良反应。方法:晚期癌痛患者43例,给予芬太尼透皮贴,3d更换1次,并酌情调整剂量,使患者24h不痛或基本不痛。结果:芬太尼透皮贴治疗中、重度癌痛的总缓解率为90.7%,不良反应以头晕、嗜睡、恶心、呕吐、便秘多见,但发生率低,程度较轻。结论:芬太尼透皮贴以其独特的透皮缓释方式,有持久稳定的镇痛作用,具有操作简便、不良反应小等优点,可作为口服强阿片类药的替代品。

OBJECTIVE： To observe the analgesic efficacy and adverse reactions of fentanyl transdermal in the treatment of advanced carcinoma pain. METHODS： 43 patients suffering from advanced carcinoma pain were administered with fentanyl transdermal system every 3 days with the dosage regulated accordingly until the patients feel painless or almost painless in 24h. RESULTS： The general remission rate was 90.7% for fentanyl transdermal in the treatment of moderate and severe cancer pain. Its main manifestations of adverse reactions were dizziness, drowsiness, nausea, vomiting and constipation, which have low incidence rates and degree of which were also low. CONCLUSION： Fentanyl transdermal system has durable and stable analgesic effect with its distinct way of transdermal slow - release, which is simple in operation and minor in adverse reactions; and it can be used as the substitutes for oral hadro- opioid.