凯时注射液治疗化疗所致药物性肝病85例

Effect of Lipo-PGE1 on drug-caused liver lesion

目的观察凯时注射液治疗化疗所致药物性肝病的效果。方法将化疗后出现药物性肝病的患者85例随机分为两组,凯时组43例,给予凯时20μg加入生理盐水250m l中静滴,1次/d;强力宁组42例,给予强力宁60m l加入生理盐水250m l中静滴,1次/d,均治疗14天后进行疗效评定,并对治疗前后ALT、A ST、-γGT等肝功指标进行对比分析。结果治疗后凯时组复常率93.0%,强力宁组54.8%(P=0.000);凯时组有效率97.7%,强力宁组81.0%(P=0.013)。各项肝功能指标对比,提示凯时的降酶作用突出。结论凯时注射液治疗化疗后所致药物性肝病有效,且效果强于强力宁。

Objective To study the effect of iniectio Lipo-PGE1 on drug-caused liver lesion following chemotherapy. Methods 85 patients with drug-caused liver lesion after chemotherapy were randomly divided into two groups. IPO-PGE1 group with 43 cases, offered Lipo-PGE1 （20 ug with saline of 250 ml ivgtt, qd） ;potenlini group with 42 cases, offered injectio potenlini （60 ml with saline of 250 ml, ivgtt, qd） The treatment outcome was evaluated after treatment of 14 days. Meanwhile the liver function markers, such as ALT,AST,γ-GT were analyzed comparatively before and after treatment. Results The rate of recovery normal in Lipo-PGE1 group was 93% ,and the effective rate up to 97.7% ;the rate of recovery normal in injectio potenlini group was 54.8% （P〈0. 01） ,and the effective rate only 81 （P≤0.05）. Liver function test showed a better effect of Lipo-PGE1 than potenlini on reducing the enzymes. Conclusion Lipo-PGE1 is better and more effective than potenlini in treating drug-caused liver lesion after chemotherapy.