摘要
通过研究新抗心律失常药甲苯喹哌(toquipidine,Toq)抗心律失常作用的心肌电生理学机制。利用微电极技术观察甲苯喹哌对豚鼠右心室乳头肌动作电位的作用,并与利多卡因进行比较。结果:Toq在1和10μmol/L时对动作电位各参数无明显影响,但在50及100μmol/L时,可明显降低动作电位的Vmax,APA,缩短APD20,APD50和APD90,并明显延长或提高动作电位的ERP,ERP/APD90和ERP-APD90利多卡因1μmol/L对动作电位各参数无明显影响。10和50μmol/L利多卡因可剂量依赖性降低Vmax,APA,缩短APD20,APD50和APD90。并明显延长ERP,ERP/PD90和ERP-APD90结论:Toq有与利多卡因类似的心肌电生理作用,但其效价强度低于利多卡因。
PURPOSE To investigae the effects of toquipidine (Toq), a new antiarrhythmic drug,on action potentials.METHODS Effects of Toq on action potentials of guinea pig papillary muscles were studied by intracellular microelectrodes.RESULTS Toq 1 and 10 μmol/L had no effects on all the parameters of action potentials. But Toq 50 and 100 μmol/L significantly inhibited Vmax, APA, APD20, APD50, APD90, and increased ERP,ERP/APD90 and ERP-APD90. Lidocaine 1μmol/L had no effects action potential. But at 10 and 50 μmol/L, lidocaine dose-dependently inhibited Vmax, APA, APD20, APD50, APD90, and increased ERP,ERP/APD90 and ERP-APD90.CONCLUSIONS Toq had a similar myocardiac electrophysiological effects as lidocaine, but itspotency was lower than that of lidocaine.
出处
《上海医科大学学报》
CSCD
1996年第1期31-33,共3页
Journal of Fudan University(Medical Science)
关键词
甲苯喹哌
乳头肌
动作电位
抗心律失常药
toquipidine
lidocaine
guinea pig
action potential
antiarrhythmic drugs