上海市普陀区1996～2003年间原发结核分枝杆菌感染的耐药性分析

Analysis of primary drug resistance of Mycobacterium tuberculosis in Shanghai Putuo district from 1996 to 2003 year

目的了解我区1996～2003年间结核分枝杆菌原发耐药性.方法采用绝对浓度法进行异烟肼(INH)、利福平(RFP)、链霉素(SM)、乙胺丁醇(EMB)4种抗结核药物的耐受性测定.结果总原发耐药率由1996～1997年的14.6%上升至2002～2003年的19.7%(上升了34.9%).耐INH、SM、RFP率由1996～1997年的8.9%、9.8%、5.7%上升至2002～2003年的15.3%、10.9%、8.0%,(分别上升了71.9%、11.2%和40.4%),耐EMB率由2.4%下降至0.7%,原发耐多药率2002～2003年为5.8%,与1996年相比,无明显上升.结论本区结核分枝杆菌原发耐药性呈上升趋势,耐多药菌株仍占一定比例.

Objective To investigate the primary drug resistance of Mycobacterium tuberculosis （M. tuberculosis ） in Sanghai Putuo district from 1996-2003. Methods Absolute concentration method was used for the detection of drug sensitivity to 4 antituberculsis agents ： isonieotinyl hydrazide （ NH ）, rifampicin （RFP） , streptomycin （ SM ） and ethambutol（EMB）. Results The rate of total primary drug resistance increased from 14.6% in 1996-1997 to 19.7% in 2002- 2003 （ increased 34.9% ）. The rates of primary drug resistance to INH, SM and RFP were 8.9% , 9.8% and 5.7% respectively in 1996-1997 and increased to 15, 3% , 10.9% and 8.0% in 2002-2003 respectively （increased 71.9% , 11.2% and 40.4% ） , while the rate of drug resistance to EMB was 2.4% in 1996-1997, and decreased to 0.7% in 2002-2003. The primary multi-drug resistance M. tuberculosis rate was 5.8% in 2002-2003, a light increase compared with 1996. Conclusions The primary drug resistance of M. tuberculosis in Sanghai Putuo district from 1996 to 2003 was in a trend of increase, but multi-drug resistance is still a serious problem.