止消温肾宁颗粒剂治疗糖尿病肾病肾功能不全代偿期31例临床观察

Clinical Observation on 31 Cases of Diabetic Nephropathy with Renal Insufficiency at Compensatory Phase Treated with Zhixiao Wenshenning Granule

目的:探讨中医药治疗糖尿病肾病的临床疗效。方法:将62例中医辨证为阳虚型的糖尿病肾病肾功能不全代偿期患者随机分为两组,各31例。对照组在基础治疗的同时加用氯沙坦,治疗组在基础治疗的同时加用中药颗粒剂止消温肾宁,3个月后观察两组的疗效,包括中医症状、肾功能等指标。结果:治疗组总有效率为74.19%,与对照组70.97%相比差异无显著性(P>0.05),但治疗组在改善症状、肾功能等方面优于对照组(P<0.05或 P<0.01)。结论:中医药治疗糖尿病肾病具有独特的优势,可明显提高该病的临床疗效。

To explore clinical therapeutic effect of TCM on diabetic nephropathy （DN）. Methods： 62 cases of diabetic nephropathy with renal insufficiency of Yang deficiency type at compensatory phase were randomly divided into two groups. The control group were treated by basic treatment plus Losartan and the treatment group were treated by the basic treatment plus Zhixiao Wenshenning Granule. Three months later, their therapeutic effects, including TCM symptoms and renal function and other indexes, were observed. Results： The total effective rate was 74. 19 % in the treatment group and 70. 97 % in the control group with no significant difference between the two groups（P〉0.05）,but the treatment group was superior to the control group in improvement of symptoms and renal function （P 〈 0. 05 or P 〈 0. 01 ）. Conclusion： TCM can obviously increase clinical therapeutic effect on diabetic nephropathy.