低频脉冲电磁场治疗骨质疏松症的Meta分析

A meta-analysis of pulsed electromagnetic fields for osteoporosis

目的:评价低频脉冲电磁场(PEMFs)治疗骨质疏松症的疗效和安全性。方法:计算机检索中国数字医院图书馆全文数据库1994年1月—2004年12月、中国生物医学文献光盘数据库1995年1月—2004年12月。由两名评价者独立对纳入文献进行质量评价,并提取资料,如有分歧,通过讨论解决。采用RevMan4.2.5进行Meta分析。结果6篇文献、共204例患者符合纳入标准,其中随机对照试验2篇。结果:骨质疏松症患者经低频脉冲电磁场治疗后与治疗前相比较,加权均数差(WMD)=0.04,95%CI为[0.02,0.06],整体效果检验Z=3.46,P=0.0005,疗效差异有极显著性意义,在森林图中,WMD的95%CI横线落在无效竖线右侧,故认为低频脉冲电磁场治疗骨质疏松症有效。低频脉冲电磁场与对照药物的疗效差异尚无显著性意义。结论:从现有的临床证据来看,低频脉冲电磁场治疗骨质疏松症有效,安全性较高,但还非常需要高质量的随机对照试验来进一步验证。

Objective：To evaluate the efficacy and safety of pulsed electromagnetic fields （PEMFs） for osteoporosis. Method ：www.chkd.cnki.net （ 1994.1 -2004.12） and CBMdisk （ 1995.1 -2004.12） were electronically searched. The quality of literature was reviewed, and the data were extracted by two reviewers independently. Meta analysis was conducted used RevMan 4.2.5 software. Result：Six controlled trial involving 204 patients were included, of the 6 controlled trial, two were of RCT. Meta analysis indicated that the WMD 0.04, 95%CI 0.02 to 0.06, test for overall effect Z 3.46, P=0.0005. After the treatment versus before treatment the divergence of curative effect had the high statistical significance. In forest plot, the 95%CI horizontal line of WMD dropped to being living the invalid upright string right side. Conclusion：Actual clinical evidence indicates that the pulsed electromagnetic fields is efficacy and safety for osteoporosis. More randomized controlled trials of high quality are needed for stronger evidence.