化疗联合G-CSF动员外周血造血干细胞疗效观察

The Efficacy of Peripheral Blood stem cells (PBSCs) Mobilized by Chemotherapy Combined with G-CSF

目的:探讨化疗联合粒细胞集落刺激因子动员外周血造血干细胞(PBSC)的效果.方法:12例恶性血液病患者采用化疗联合G-CSF进行PBSC动员和采集,并检测采集物中单个核细胞计数(MNC)和CD34+细胞.结果:12例患者均一次即获足量干细胞,获MNC平均5.7(2.2～7.6)×108/kg,CD34+细胞平均15.2(2.5～26.9)×106/kg.未出现严重不良反应.结论:化疗联合G-CSF能安全、高效地动员PBSC,满足移植的需要.

Objective： To observe the efficacy of peripheral blood stem cells （PBSCs） mobilized by chemotherapy combined with recombinant human granulocyte colony stimulating factor. Method：We associated G - CSF with chemotherapy in 12 patients with malignant hematologic disease to mobilization and extraction the peripheral blood stem cell, and the number of mononuclear cells and CD34^ ＋ cells was monitored. Result：All the patients obtained enough cells from extraction in one time, the average number of MNC was 5.7 （2.2 -7.6）×10^8/kg, CD34^＋ cells was 15.2 （2.5 -26.9） ×10^6/kg, there are no severe disadvantage reactions. Conclusion： Mobilization of peripheral blood stem cell with chemotherapy combined with G - CSF is a safe and high- efficiency method. It can satisfy with the transplant.