红细胞免疫功能与阻塞性睡眠呼吸暂停综合征

The Effect of Erythrocyte Immune Function on OSAS

目的：探讨红细胞表面补体受体(CR1) 、CD58抗原对阻塞性睡眠呼吸暂停综合征(OSAS)患者发病的作用。方法：选择 OSAS 住院患者20例，同年龄组健康对照组15例。取清晨空腹新鲜全血3 ml，测定肿瘤红细胞花环率(ECR1) 代表红细胞膜 CR1活性，应 用流式细胞仪检测红细胞膜表面 CD58表达，以此评价红细胞免疫功能在疾病发病中的调节作用。结果：OSAS 患者研究组肿瘤红细 胞花环率与对照组相比有显著差异(P＜0． 05) ；OSAS 患者研究组红细胞 CD58表达与对照组相比有显著差异(P＜0． 01) 。直线相关 性检验分析显示 OSAS 患者呼吸暂停/低通气指数(AHI)与 CR1活性、CD58表达无明显相关性。结论：红细胞免疫功能紊乱在 OS- AS 发病机制中，尤其是免疫网络的相互作用中，具有一定的调节意义。

Objective To investigate the effect of CR1 ,CD58 on erythrocytic membrane surface on obstructive sleep apnea sydrome （OSAS） . Methods 20 in hospital patrents with OSAS and 15 healthy controls of the same age were enrdled. 3ml fresh whole blood with stom- ach empty in early morning were collected to detect erythrocytes cancer cell rosette （ECR1） representing the activity of CR1 on erythrocyte membrane surface. Use flow cytometry to examine the expression of CD58 on erythrocyte membrane surface to evaluate the accommodation effect of erythrocyte immune function on disease invasion. Results The ECR1 of the OSAS group was lower than that of thet controls group （P〈0. 05）. The expression of CD58 was significantly higher in OSAS group than that of control group（P〈0. 01） . There was no significant correlation between CR1 activity, CD58 and AHI expression by linear correlation test. Conclusion Erythrocyte immune functional disorder plays an important accommndative role in OSAS pathegensis especially the interaction of immunological network.