摘要
为探讨He-Ne激光对慢性萎缩性胃炎(CAG)大鼠胃黏膜的影响,将52只成年雄性Wistar大鼠随机分成正常组、非治疗组及各激光治疗组。应用2%水杨酸钠和30%酒精的混合溶液灌胃8周,刺激大鼠胃黏膜,并结合劳累、饥饱失常等多因素方法建立大鼠CAG模型,各治疗组在造模完成后,分别给予不同剂量(6.24J·cm-2,4.80J·cm-2,3.36J·cm-2)的He-Ne激光照射,每日一次,连续20d,观察各组大鼠胃黏膜的变化。发现3.36J·cm-2的He-Ne激光组与非治疗组比较,胃黏膜变厚(P<0.01),炎细胞减少(P<0.05),细胞形态、结构、体积、均恢复或接近正常;CyclinD1的阳性表达率较高(P<0.05)。表明3.36J·cm-2的He-Ne激光照射能够促进CAG大鼠的胃黏膜功能恢复,疗效显著。
This study sought to explore the effects of He-Ne laser irradiation on the gastric mucosa of experimental chronic atrophic gastritis （CAG） in rat. Fifty-two male adult Wistar rats were randomly divided into five groups including normal control group, model group and three different doses He-Ne laser groups. The CAG model in rats was made by administering （per gastrogavage） a compositus liquor, including 2% sodium salicylate and 30% alcohol ,for 8 weeks to stimulate the rat＇s gastric mucosa, combined with irregular fasting and compulsive sporting as pathogenic factors. He-Ne laser therapy was used at different doses of He-Ne laser, once a day for twenty days, then the morphological changes and the expression of cyclinD1 were observed. Compared with untreated group, the gastric mucosa of 3.36J ·cm^-2 He-Ne laser group was significantly thicker （P〈0.01）, the inflammatory cells of gastric mucosa were decreased （P〈0.05）, the morphology, structure and volume of the cells were restored or nealry norma and the expressions of cyclinD1 were higher （P〈0.05）. In a word, small dose He-Ne laser （3.36 J·cm^-2） has a good adjuvant therapeutic effect on rat＇s CAG.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
2005年第5期926-929,共4页
Journal of Biomedical Engineering
基金
河北省自然基金资助项目(301427)
