摘要
目的:观察米多君治疗女性压力性尿失禁(SUI)的临床效果和尿动力学变化。方法:19例SUI病人予米多君2.5 mg,po,tid,疗程4 wk。观察治疗前后尿失禁等级评分(MHU)、尿失禁自我评价(ICIQ)和尿动力学检查结果。结果:19例病人治疗前后临床有效率74%(14/19);主观症状ICIQ评分和MHU评分均明显下降,差异有非常显著意义(P<0.01)。最大尿流率下降,最大尿道外压、最大尿道闭合压和腹腔漏尿点压力治疗后升高(P<0.01或P<0.05);而最大膀胱测量容量和功能性尿道长度治疗前后无显著差异(P>0.05)。结论:米多君治疗女性SUI有效,其尿动力学原理为提高尿道的闭合压力。
AIM:To investigate the clinical efficacy and urodynamic changes of midodrine in treatment of female stress urinary incontinence (SUI). METHODS: Nineteen female patients with SUI were given midodrine 2.5 mg, thrice daily for a course of 4 wk. The involved data of urodynamics, urinary stress, incontinence clinical level scores (MHU) and self-ratings (ICIQ) were collected before and after treatment. RESULTS: After treatment, the clinical total efficacy rate reached 74 % (14/19)with decrease of the ICIQ and MHU scores significantly ( P 〈 0.01 ). MaxPura, MaxPclo and SLPP were increased ( P 〈 0.05 ) , but no significant differences occured in MCC and functional profile length (FPL) before and after the treatment( P 〉 0.05 ). CONCLUSION : Midodfine is effective in treatment for female SUI due to increasing urethral closure pressure.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2005年第11期900-902,共3页
Chinese Journal of New Drugs and Clinical Remedies
关键词
米多君
尿失禁
压力性
药物疗法
尿动力学
midodrine
urinary incontinence,stress
drug therapy
urodynamics