黄芩上清口服液主要药效学研究

Studies on main pharmacodynamic of Huangqin Shangqing oral liquid

目的研究黄芩上清口服液的抗炎、解热、镇痛和体外抑菌作用.方法采用小鼠耳壳肿胀法,伤寒、副伤寒甲乙三联菌苗导致家兔发热反应以及小鼠扭体法观察黄芩上清口服液的抗炎、解热、镇痛作用,采用平皿二倍稀释法测定黄芩上清口服液的最低抑菌浓度(MIC).结果黄芩上清口服液抑制二甲苯所致小鼠耳壳肿胀及醋酸所致小鼠扭体反应,并具有明显的抑制伤寒、副伤寒甲乙三联菌苗所致家兔发热反应作用;黄芩上清口服液对6株菌的MIC范围为13.5～432 mg/ml.结论黄芩上清口服液具有明显的抗炎、解热、镇痛及体外抑菌作用.

Objective To study the anti-inflammatory, antipyretic and analgesic effects of Huangqin Shangqing oral liquid and to explore its in-vitro antibacterial actions. Methods Auricular swelling method in mice,typhoid and paratyphoid vaccines-induced fever in rabbits and body twisting test in mice were used respectively to observe the anti-inflammatory,antipyretic and anaIgesic effects of Huangqin Shangqing oral liquid, Results Huangqin Shangqing oraI liquid could inhibit xylene-induced auricular swelling and body twisting response reaction induced by acetic acid in mice. Huangqin Shangqing oral liquid also reduce the vaccines-induced fever in rabbits. MIC of Huangqin Shangqing oral liquid for 6 bacterial strains ranged 13.5 mg/ml to 432 mg/ml. Conclusion Huangqin Shangqing oral liquid has a significant anti-inflammatory, antipyretic and analgesic effects and exert in-vitro antibacterial action.