摘要
目的研究氮酮对阿糖胞苷乳膏体外透皮吸收的影响。方法采用小鼠离体皮肤作为渗透屏障,研究不同浓度氮酮对阿糖胞苷促渗作用的影响。结果5%氮酮可显著提高阿糖胞苷对皮肤渗透作用,其稳态流量(J)比空白乳膏增加了70.94%。结论阿糖胞苷乳膏具有良好的皮肤渗透性,本试验为阿糖胞苷经皮给药制剂在临床的应用,提供了安全、有效的理论依据。
Aim To study the effect of azone on Cytarabine for perceutanous absorption. Methods Rats skin in vitro was apphed, studying the effect of different concentrations of azone in Cytarabine ointment on drug permeation. Results 5 % azone increased the perceutanous permeability of Cytarabine, steady percutanous speed （J） of Cytarabine ointment increased 70.94%. Conclusion Cytarabine cream has good perceutanous permeability. Cytarabine cream will be a safe, effective and convenient new preparation.
出处
《解放军药学学报》
CAS
2005年第5期377-378,共2页
Pharmaceutical Journal of Chinese People's Liberation Army
关键词
阿糖胞苷
氮酮
透皮吸收
Cytarabine
Azone
Perceutanous absorption
