双芳基脲衍生物的合成

Synthesis of Diarylurea Derivatives

脲类化合物所表现出来的优良的生物活性已引起许多科学家的重视,含有—NHCO—基团被认为是抑制酶的活性基本骨架,具有广泛的生物活性。用取代苯胺和苯异氰酸酯反应合成了5个双芳基脲衍生物,对产物进行了元素分析,以红外光谱和氢核磁共振谱确认其结构。

Good bioactivities urea have attached the attention of chemical experts. The groups with peptide bond or similar parts are considered as basic framework that can restrain the activities of enzyme. The urea compound containing the ——CONH radicle have the extensive living creature activity.In this thesis, five diarylurea derivatives were synthesized by reacting substituted phenylaniline with isocyanate. IR and HNMR are used to analyze its component element. According to the results ,we can verify its structure and identify.