摘要
香豆素类物质在植物中分布广泛,是豆香型香料的主要成份之一,常用于日用香精中。秦皮中的秦皮甲素,补骨脂中的补骨脂内酯,另外,双香豆素,6,7-二甲氧基香豆素,7,8-二甲氧基香豆素,6-羟基-7-甲氧基香豆素等均属香豆素类物质。目前国内多数是植物(绝大多数为中药)提取物中香豆素类物质的定性或定量分析。国外的文献则偏重于香豆素作为药物在生物体中的代谢机理和生理毒性。色谱检测中应用最多的仪器是高效液相色谱。国外还报道了几种特别的高效液相色谱改进技术:胶束电动毛细管技术,凝胶溶胶通道技术,直角纳米通道技术,二维技术。另外,液质联用技术,薄层色谱和柱色谱,超临界流体色谱法,气相色谱也可用于香豆素的检测。
Coumarin substances, which exist in the plants comprehensively ,are the main spice materials and always used in the daily spice. It contains esculin, psoralen, dicoumarin, 6,7-dimethoxy coumarin, 7,8-dimethoxy coumarin, and 6-hydroxy-7-methoxy coumarin, the coumarin has some medical use, for example, restricting the tumor and enlarging the artery. The articles about coumarin compounds is usually about its qualification and quantification in the plants（many are Chinese traditional medicine） abstracts in China or the metabolic mechanics and physiological toxicity of the coumarins as medicines in the organism overseas. The HPLC is the most usually used machine in the detect of coumarin. Some betterments have used in the HPLC： Micellar Electrokinetic Capillary Chromatography（MECC）, Sol-gel Electro-Chromatography, Flat-Rectangular Nano-Channels, Two-Dimensional Liquid Chromatography. Besides, HPLC-MS, TLC, SFC, and GC also can be used in the detection of coumarins.
出处
《生命科学仪器》
2005年第5期34-38,共5页
Life Science Instruments
