硫普罗宁致过敏性休克38例文献分析

Literature review of 38 cases with tiopronininduced anaphylatic shock

目的:探讨硫普罗宁致过敏性休克的特点和诱发因素,为临床合理使用硫普罗宁提供参考。方法:通过在线检索《中国医院数字图书馆》2000年1月-2005年6月国内公开发行的医药期刊中有关硫普罗宁致过敏性休克病例报道28篇,共计38例进行统计与分析。结果:38例中男性显著多于女性(P<0.01);全部患者使用常规剂量静脉给药;86.84%(33/38)的患者在用药后30min内发生过敏性休克(P<0.01);过敏性休克的临床症状以血压剧降、胸闷、呼吸困难和寒战等为主,皮肤过敏反应不多见;81.58%(31/38)的患者过敏性休克在1h内被纠正(P<0.01);97.37%(37/38)的患者经抗过敏性休克治疗痊愈(P<0.01)。结论:掌握硫普罗宁所致过敏性休克的特点将有助于该药的合理使用。

Objective： To investigate the characteristics and causative factors of tiopronin-induced anaphylatic shock for its rational use in clinic. Methods： Domestic medicine periodicals were searched between January 2000 and June 2005, and 38 cases with tiopronin-induced anaphylatic shock were analysed. Results： Routine dosages of tiopronin were administered by intravenous infusion in all cases. 86.84% of the cases developed anaphylactic shock within 30 minutes after administration, more male than female （P〈0.01）. Clinical symptoms of anaphylactic shock were mainly repid decrease in blood pressure, chest distress, dyspnea and chill. Allergic reactions of skin were uncommon. 97.37% of the cases（37/38） were recovered after treatment, and most cases（ 81.85%, 31/38）improved within one hour. Conclusion： Physicians should attach importantce to the rational use of tiopronin in clinical practice.