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脑缺血-再灌注后细胞凋亡的Caspase-3机制 被引量：5

Mechanism on the Neuronal Apoptosis and the Expression Caspase-3 gene after Focal Cerebral Ischemia Reperfusion
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摘要 脑缺血-再灌流后细胞凋亡的发生与Caspase-3密切相关。缺血-再灌流后,自由基的产生、细胞器的损伤、促凋亡因子释放等都会使Caspase-3 mRNA表达增强诱导凋亡。 The neuronal apoptosis after focal cerebral ischemia reperfusion is correlated intimately with the expression of caspase - 3 gene, the production of free rediele,the injury of cellular organs,the release of crowded apoptosis factors and so on that can enhance the expression of caspase- 3, which induce the neuronal apoptosis.
作者 陈蓉 林燕 张英
机构地区 四川省泸州医学院病理生理教研室
出处 《黑龙江医学》 2005年第11期823-825,共3页 Heilongjiang Medical Journal
关键词 脑缺血-再灌流 细胞凋亡 CASPASE-3 机制 Cerebral Ischeania Reperfusion Apoptosis Caspase - 3 Mechanism
分类号 R363 [医药卫生—病理学]
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  • 1Schmidt-Kastner R, Truettner J, Zhao W, et al. Differential changes of bax, caspase-3 and p21 mlLNA expression after trmasieut focal brain ischema in the rat [J]. Brain Res Mol Brain Res,2000,79:88-101.
  • 2Ramuz O, lsnardon D, Devilard E, et al. Constitutive neclear localization and initial cytoplasmic apoptotie activation of endogenous caspase-3 evidenced by confocal micn~scopy [J]. Int J Exp Pathol,2003,84:75-81.
  • 3IRU,Janieke, Ng P. Sprenggml ML, d al. Caspase-3 is required for α-fodrin cleavage but dispensable for cleavage of other death substrate in apoptosis [J] .J Biol Chem, 1998,273:15540-15545.
  • 4Kitazawa M, Anantharanl V, Kmlthasamv AG. Dieldrin induces apoptosis by promoting caspase-3-dependent proteolytic cleavage of protein kinase Cdelta in dolmminergic cells: relevance to oxidative stress and dopaminergic degeneration [ J ]. Neuroscience, 2003,119:945-964.
  • 5Eanfi M,Sakahira H, Yokoyama H, et al. A caspase-activated Dnase that deoades DNA during apoptosis and its inhibitor ICAD [J]. Nature, 1998, 391 : 43-50.
  • 6Wolf BB, Schuler M, Echeverri F, et al. Caspase-3 is the primary activator of apolptotic DNA fragmentationinhibitor of caspase-activaled DNase inactivation [J] .J Biol Chem, 1999,274:30651-30656.
  • 7Han 7, Malik N, Carter Y,et al.DNA-dependent protein kinase is a target for a CPP32-1ike apolptotic protease [J]. J Biol Chem,2000,273:25035- 25040.
  • 8Veltkamp R, Domoki F, Bail F, et al. Inhibitors of protein synthesis preserve the N-methyl-D-aspartate-induced cerebral arteriolar dilation after ischemia in piglets[J]. Stroke, 1999,30:148-152.
  • 9Eamshaw WC, Martins LM Kaufinann SH. Mammalian caspase: structure,activation, substcrates, and functions during apoptosis [J]. Annu Rev Biochem, 1999,68 : 383-424.
  • 10Yuan J, Yankner BA. AtxJptosis in the nervous system [J]. Nature,2000, 407:802-809.

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黑龙江医学
2005年 第11期

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