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当归对CC1_4所致肝损伤大鼠的抗肝纤维化作用 被引量:20

Effect of Radix Angelicae Sinensis on hepatic fibrosis in rat With chroinc CC 14-induced liver injury
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摘要 将120只SD大鼠随机分为5组,在腹腔注射CC1_4的同时,于不同实验阶段投予当归注射液。12周后,取肝脏作VG和HE染色,以观察肝纤维化程度及肝内胶原含量的变化。结果表明,早、中期投予当归注射液组,其肝纤维化程度显著轻于后期投药组,肝内胶原含量亦显著少于后者。提示当归可显著减轻肝纤维化程度,似不能促进己沉积的胶原降解。 Radix Angelicae Sinensis (RAS) has the prophylactic and therapeutic effectson portal hypertension in the rat with chionic CC14-induced liver injury. One-hundredand tWenty Sprague-Dawley rats were divided into five groups, including group Ⅰ re-ceivtu normal saline,group Ⅱ injected CC14 plus normal saline,group Ⅲ、Ⅳ、Ⅴ withCC14 plus RAS started from the lst, 5th and 9th week,respectively. The results showedthat the score in group Ⅰ~Ⅴ was 0,1.81±1.02,1.29±0.81,1.47±0.62 and 1.88±0.93respectively and the sndace densities of hepatic collagen were 1.58±0.43,15.97±5.86,7.70±3.63,9.01±4.11l and 14.94±7.70,respectively(F=78.86,P<0.001).It was concluded thatRAS inhibited the proliferation of hepatic collagen,but didn’t seem to promote itsdegradation in the rat with chronic CC14 - induced liver injury.
出处 《中国病理生理杂志》 CAS CSCD 北大核心 1996年第2期152-154,共3页 Chinese Journal of Pathophysiology
关键词 肝硬化 四氯化碳 当归 中草药 Carbon tetrachloride·Liver cirrhosis·Radix Angelicae Sinensis
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参考文献9

  • 1黄自平,中国病理生理杂志,1995年,11卷,187页
  • 2林迎晖,药学学报,1994年,29卷,171页
  • 3汪晖,中国药理学报,1994年,15卷,81页
  • 4黄自平,中华消化杂志,1994年,14卷,31页
  • 5黄自平,临床肝胆病杂志,1993年,9卷,32页
  • 6黄自平,中国病理生理杂志,1993年,9卷,200页
  • 7黄自平,中国中西医结合杂志,1993年,13卷,特集,183页
  • 8黄自平,中华消化杂志,1992年,12卷,173页
  • 9仲来福,中国药理学与毒理学杂志,1989年,3卷,298页

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