摘要
将120只SD大鼠随机分为5组,在腹腔注射CC1_4的同时,于不同实验阶段投予当归注射液。12周后,取肝脏作VG和HE染色,以观察肝纤维化程度及肝内胶原含量的变化。结果表明,早、中期投予当归注射液组,其肝纤维化程度显著轻于后期投药组,肝内胶原含量亦显著少于后者。提示当归可显著减轻肝纤维化程度,似不能促进己沉积的胶原降解。
Radix Angelicae Sinensis (RAS) has the prophylactic and therapeutic effectson portal hypertension in the rat with chionic CC14-induced liver injury. One-hundredand tWenty Sprague-Dawley rats were divided into five groups, including group Ⅰ re-ceivtu normal saline,group Ⅱ injected CC14 plus normal saline,group Ⅲ、Ⅳ、Ⅴ withCC14 plus RAS started from the lst, 5th and 9th week,respectively. The results showedthat the score in group Ⅰ~Ⅴ was 0,1.81±1.02,1.29±0.81,1.47±0.62 and 1.88±0.93respectively and the sndace densities of hepatic collagen were 1.58±0.43,15.97±5.86,7.70±3.63,9.01±4.11l and 14.94±7.70,respectively(F=78.86,P<0.001).It was concluded thatRAS inhibited the proliferation of hepatic collagen,but didn’t seem to promote itsdegradation in the rat with chronic CC14 - induced liver injury.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1996年第2期152-154,共3页
Chinese Journal of Pathophysiology
关键词
肝硬化
四氯化碳
当归
中草药
Carbon tetrachloride·Liver cirrhosis·Radix Angelicae Sinensis