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骨质疏松的分子遗传学研究进展 被引量：1

Progress in the study of molecular genetics of osteoporosis
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摘要 遗传因素在骨质疏松的发病中起重要作用。本文简要介绍近年来在骨质疏松相关基因关联分析方面所取得的研究进展,并对新近发现的LRP5基因在骨量维持中作用的研究进展进行了重点介绍,LRP5基因在骨量和骨密度调控中起着关键作用。 Genetic factors play important proved to be involved. In this We also present the extensive paper, we genetic and roles in reviewed pathogenesis of osteoporosis, but few genes have the relationship between some susceptibility genes functional data indicating that the LRP5 gene and the Wnt are essentially responsible for bone formation and the risk of osteoporosis been definitively and osteoporosis. signaling pathway
作者 朱国明 龚瑶琴
机构地区 山东大学医学遗传学研究所实验畸形学教育部重点实验室
出处 《基础医学与临床》 CSCD 北大核心 2005年第11期969-974,共6页 Basic and Clinical Medicine
关键词 骨质疏松 分子遗传学 低密度脂蛋白受体相关蛋白5 基因多态性 osteoporosis molecular genetics LDL-receptor-related protein 5 polymorphism
分类号 R58 [医药卫生—内分泌]
  • 相关文献

参考文献41

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二级参考文献10

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共引文献4

同被引文献19

  • 1苏欣,廖二元,彭健,伍贤平.雌二醇对人成骨肉瘤MG63细胞株护骨素、护骨素配体及其相关因子的调节[J].中华内科杂志,2003,42(11):800-803. 被引量：13
  • 2姚静,侯加法.OPG/RANKL/RANK系统的研究进展[J].动物医学进展,2006,27(2):5-9. 被引量：25
  • 3张红,罗湘杭,谢辉,伍贤平,单鹏飞,曹行之,廖二元.基质金属蛋白酶-1、-2与女性年龄、骨转换生化指标及骨密度的关系[J].中华内科杂志,2006,45(4):306-309. 被引量：30
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基础医学与临床
2005年 第11期

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