摘要
雄性大耳白兔25只,采用免疫损伤合并高胆固醇(1%)喂饲40天,造成动脉粥样硬化(AS)模型,然后随机分四组:模型组(M组)立即处死;对照组(C组)喂普通饲料;治疗组又分两组,均喂普通饲料75天,其中尼群地平组(N组)同时每天每只口服尼群地平40mg,赤芍组(P组)同时服赤芍煎剂(按每千克体重每天含生药10g配制)。结果:各组主动脉AS病灶面积百分比为:M组58.1%,C组68.1%,N组27.5%,P19.6%;各组冠状动脉AS病灶面积百分比分别为:M组60.6%,C组43.5%,N组19;7%,P组26.6%。提示尼群地平、赤芍可促进AS病灶的消退。
Twenty-five male rabbits were injured with immunoreaction and fed a 1% cholesterol diet for forty days,then they were divided into four groups.Rabbits in M group were killed immediately,those in other three groups were fed with stock diet for seventy-five days(C group),only those in N group added nitrendipine(NT) 40 mg daily,those in P group added radix paeoniae rubra(RPR)10g·kg-1/L daily. The results showed that percentage of surface of aortic atherosclerosis lesion was:M 58.1%,C 68.1%,N 27.5%,P 19.6%;pescentage of surface of coronary arteries atherosclerosis lesion was: M 60.6%、C43.5%、N 19.7%、P26.6%.This study suggested NT and RPR could regress atherosclerotic lesion.
出处
《临床心血管病杂志》
CSCD
北大核心
1996年第3期164-167,共4页
Journal of Clinical Cardiology
基金
湖北省教委95年青年课题
关键词
动脉粥样硬化
尼群地平
赤芍
Atherosclerosis
Regression
Nitrendipine
Radix paeoniae rubra