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胺碘酮和美西律治疗冠心病并室性心律失常56例疗效比较 被引量:1

Effect of amiodarone and mexiletine on ventricular arrhythmias in 56 patients with coronary heart diseases
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摘要 目的比较胺碘酮和美西律治疗冠心病心肌缺血患者室性心律失常的疗效。方法56例冠心病心肌缺血合并室性心律失常患者,均接受冠心病正规治疗,其中30例同时口服胺碘酮片(胺碘酮组),26例口服美西律片(美西律组),疗程4周。疗程开始及结束时均行24h动态心电图及12导联心电图检查。结果两组患者用药后24h室性早搏、短阵室性心动过速的发作次数均明显减少,胺碘酮组用药后与用药前比较分别为(2801±356)个和(6935±1427)个,(1.28±0.92)次和(7.39±3.31)次;美西律组则分别为(3958±966)个和(6726±1395)个,(4.25±2.61)次和(8.10±3.32)次,P均<0.01。胺碘酮组的疗效高于美西律组(P<0.01)。两组均未见严重副作用。结论胺碘酮对冠心病伴室性心律失常的疗效优于美西律。 Objective To investigate the effect and safety of amiodarone (Cordarone) and mexiletine on ventricular arrhythmias (VAs)in patients with coronary heart diseases (CHD). Methods 56 CHD patients with VA were randomly divided into 2 groups. 30 patients were given with amiodarone (amiodarone group) and 26 patients were given mexiletine (mexiletine group).Results In both groups, the occurrence of ventricular arrhythmias were reduced markedly.Premature ventricular beats and paroxysmal ventricular tachycardias before and after treatment in amiodarone group were (2801± 356)beats/24 h versus (6935 ±1427)beats/24 h and (1.28±0.92) times/24 h versus (7.39±3.31) times/2.4 h respectively (P〈0.01).And in mexiletine group were (3958±966) beats/24h versus (6726±1395)beats/24 h and (4.25± 2.61) times/24 h versus (8.10±3.32) times/24h respectively (P〈0.01). The effect of amiodarone was better than mexiletine(P〈0.01).No heart function deterioration occurred in both group. Conclusion Amiodarone is effective on VAs in patients with CHD and more effective than mexiletine.
出处 《中国心血管病研究》 CAS 2005年第12期920-922,共3页 Chinese Journal of Cardiovascular Research
关键词 胺碘酮 美西律 冠状动脉疾病 心律失常 Amiodarone Mexiletine Coronary disease Arrhythmia
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