还原型谷胱甘肽对药物性肝损的治疗探讨

The effect analysis of on the drugs liver lesion

目的了解还原型谷胱甘肽治疗药物性肝损的疗效.方法在治疗过程中出现药物性肝损时,治疗组每天用1.8 g还原型谷胱甘肽加入生理盐水250 ml中静滴,对照组则以维生素C 2g替代还原型谷胱甘肽,两组疗程均25～30天,疗程满后再次复查肝功能以评定疗效,对比两组的疗效,用χ2检验两者的差异显著性.结果实验组和对照组治疗有效率分别为88.3%和73.3%(P＜0.05),两者存在显著性差异.结论提示还原型谷胱甘肽对治疗药物性肝损有效.

Objective To observe the effect of on the drugs liver lesion. Methods The treatment group was given at a dose of 1.8 g with GSH d-1 for 25 - 30 days, dissolyved with 0. 9% concentration N. S 500 ml by intravenous drip, and control group was given vitamini C at a dose of 2. 0 g d-1 instead at the same time take the norman liver function as effective in therapy after retest the liver function, compare the effective rate and sinificant differance between the two groups using x2. Results The effective rate of tile treatment group （88. 3% ） was higher than the control group （73.3%） （P 〉 0. 05 ）, there were significant difference between them. Conclusion There is effective in therapy of drugs liver lesion.