摘要
近来,我们在流感监测中,发现了甲型流感病毒发生了相变异。据我们所知,H3N2亚型毒株发生相变为首次发现。"O"相毒株的出现,宣告了鸡胚已不是流感病毒最敏感的宿主,鸡红细胞已不是流感病毒红细胞测定中最理想的细胞。同时指出了,虽然狗肾传代细胞(MDCK Cells)对当前人群中所流行的流感病毒敏感性较高,但它是传代细胞有致癌性,由它分离出的病毒不能用于疫苗生产。故寻找一种对流感病毒敏感又不具有致癌性的细胞已刻不容缓。
In the course of influenza surveillance,the phase change of influenza A virus was found recently.To our knowledge,this is the first report of finding phase change of influenza A(H3N2)virus.The appearance of'O' phase strain of influenza virus in men pointed out that the emhryonated hen eggs were no longer the most sensitive host of influenza viruses and that the chicken red blood cells used in HA test were not satisfactory either.Although the Madin-Darby Canine Kidney(MDCK)cell line is more sensitive than emhryonated chicken eggs to influenza viruses circulating in man recently,it is a continuous line with oncogenous factor,the viruses isolated with MDCK cells can not be used for vaccine production.Now searching the cells sensitive to influenza viruses without oncogenous factor are urgently needed.
出处
《中华实验和临床病毒学杂志》
CAS
CSCD
1996年第2期101-103,共3页
Chinese Journal of Experimental and Clinical Virology