摘要
目的评价培哚普利治疗中度原发性高血压的有效性和安全性并与卡托普利比较。方法 120例患者随机分为培哚普利组(60例)和卡托普刘组(60组),每组中44例行偶测血压监测,16例行动态血压监测;培哚普利4~6 mg,1/d,卡托普利12.5~18.75 mg,3/d,疗程4周。结果降压总有效率培哚普利组为91.7%,卡托普利组为78.3%(P<0.05);副作用发生率培哚普利组为11.7%,(卡托普利组为28.3%(P<0.05),且均较轻微。结论培哚普利治疗中度原发性高血压疗效较好而且安全。
Aim To investigate the efficacy and safety of perindopril in patients with moderate hyper- tension and compared with captopril.Methods 120 cases were randomly assigned into two groups. Perindopril group(n=60)4 to 6mg/d and captopril group(n=60)12.5 to 18.75mg 3/d for 4w.32 cases were evaluated by 2.4h ambulatory blood pressure monitoring,while 88 cases were evaluated by sphy- momanometer.Results The total efficacy was 91. 7% in the perindopril group and 78.3% in the captro- pril group.Conclusion Perindopril is more effec- tive and safe on moderate essential hypertension.
出处
《高血压杂志》
CSCD
1996年第2期147-149,共3页
Chinese Journal of Hypertension
关键词
高血压
动态血压监测
培哚普利
卡托普利
essential hypertension
ambulatoy blood pressure monitoring
perindopril
captopril