基因重组卵泡刺激素促排卵效果的观察

Observing the ovulation-promotion effect of gene recombinant follicle stimulating hormones

目的比较在体外受精-胚胎移植(IVF-ET)及卵母细胞单精子显微注射(ICSI)中尿促性素(menotropins,HMG)和重组卵泡刺激素的作用。方法采用促性腺激素释放激素激动剂(GnRH-a)方案降调节,月经第3天随机分成两组,给予两种不同的促性腺激素(Gn)促排卵。A组51例,用国产HMG促排卵;B组58例,采用基因重组卵泡刺激素(rFSH)促排卵,至卵泡成熟后,经阴道B超引导下取卵。按本中心常规方法行IVF/ICSI。结果两组平均获卵率、空卵率、优质胚胎数、受精率、卵裂率、临床妊娠率、ICSI后卵子的死亡率差异有统计学意义。结论应用rFSH促超排卵可获得足量的高质量卵子。

Objective To compare the effects of menotropins （HMG） and recombinant follicle stimulating hormone （rFSH, Gonal-F） in vitro fertilization-embryonic transplantation （IVF-ET） and intracytoplasrnic sperm injection （ICSI）. Methods All of them accepted gonadotropin releasing hormone agonist （GnRH-a） down-regulation, they were divided into two groups randomly on the 3rd day of menstruation, HMG was used in group A （ n = 51 ）, but r-FSH was used in group B （n = 58）; retrieving eggs when the leading follicles reached 18 mm. Results There was statistical difference between the two groups in the number of oocytes retrieved, empty follicle rate, the number of high quality embryos, fertilization rate, embryo cleavage rate, clinical pregnancy rate and the death rate of oocyte after ICSI. Conclusion Ovarian stimulatingwith r-FSH may obtain enough high quality oocytes.