摘要
环糊精及其衍生物通过非共价结合的包合作用或与药物形成共轭化合物,在提高溶解效率、改善药剂性能和方便药物传输等方面得到了广泛的应用。近年来,环糊精及其衍生物还被用作治疗性基因载体和某些蛋白质生物大分子的新型药物制剂材料,从而开辟了一个崭新的前沿研究领域。
Cyclodextrin and its derivatives have been applied widely in improving pharmaceutical properties (such as solubility and formulation) and enhancing drug delivery through their inclusion effects or formation of conjugated compounds. Recently, they gene therapy and as a novel formulation material of new research frontier in pharmaceutical sciences were exploited as a carrier for oligonucleotide delivery in therapeutic macromolecules, thereby opening an entirely
出处
《中国新药杂志》
CAS
CSCD
北大核心
2005年第11期1261-1264,共4页
Chinese Journal of New Drugs
基金
国家重大科技专项项目(2002AA2Z3343)
中国科学院知识创新工程重大项目(KSCX1-SW-11-2)
关键词
环糊精
环棚精衍生物
包合物
共轭化合物
cyclodextrin
cyclodextrin derivatives
inclusion compound
conjugated compound