新型棘白菌素类抗真菌药阿尼芬净

Anidulafungin;a new echinocandin antifungal agent

阿尼芬净(anidulafungin,VER-002;LY303366),是第三代棘白菌素类的半合成抗真菌药,是两性霉素B的衍生物,由美国Vicuron制药公司研制,同其他棘白菌素类抗真菌药比较,分布容积更大,抗菌谱更广,目前在美国处于Ⅲ期临床试验阶段。介绍阿尼芬净的作用机制、药效学、药动学和临床评价。

Anidulafungin （Vieuron Pharlnaceutieals） is a new echinocandin antifungal with potent activity against Aspergillus and Candida spp. Anidulafungin is a noncompetitive inhibitor of （1,3）-beta-Dglucan synthase within thngal cells. Its features include a larger distribution volume and potentially broader and more potent antifungal activities than other echinocandins. Anidulafungin is in Phase Ⅲ stage of clinical studies in USA. This paper introduces the mechanism, pharmacodynamies, pharmacokinetics and clinical therapeutics of anidulafungin.