摘要
目的:分析原发性中枢神经系统淋巴瘤的临床特点,提高临床诊断率。方法:结合文献对4例原发性中枢神经系统淋巴瘤患者的临床特点、病理学检查、影像学表现、治疗及预后进行回顾性分析。结果:4例患者以颅内压升高和神经功能缺损为主要临床表现,病理检查结果均为非何杰金淋巴瘤(B细胞型)。4例均行手术切除,术后给予联合放化疗、单纯化疗或放疗,至随访终点,2例患者死亡,平均存活时间为20个月。结论:原发性中枢神经系统淋巴瘤的诊断需结合临床特点和影像学表现来综合判定,确诊必须依赖病理学检查;原发性中枢神经系统淋巴瘤预后不佳,手术治疗是PCNSL的主要治疗方法,术后应积极放化疗。
Aim： To study the clinical characteristics of primary CNS lymphoma and improve the accuracy of clinical diagnosis.Methods： In combination with literatures, the clinical characteristics as well as the features of images, pathology and therapeutic efficacy of 4 cases of primary CNS lymphomas were retrospectively analyzed. Results：Tbe cohort included 3 men and 1 woman whose median age at 65 years. The pathological examinations were B lymphocyte origin. At the end point of the follow-up,2 died. The median survival time for the patients in study was 20 months. Conclusion：The diagnosis of primary CNS lymphoma must be set up by pathological examination in combination with clinical characteristics and images. The prognosis appears dismal despite an intensive muhidisciplinary therapeutic approach.
出处
《中国临床神经科学》
2005年第4期389-391,395,共4页
Chinese Journal of Clinical Neurosciences
关键词
淋巴瘤
中枢神经系统
诊断
治疗
lymphonm
central nervous system（CNS）
diagnosis
therapy
