老年慢性支气管哮喘患者血清TNF-α、IL-6水平及其临床意义

Clinical Significance of Changes of Serum TNF-α and IL-6 Levels in Eldery Patients with Chronic Bronchial Asthma

目的:探讨了老年慢性支气管哮喘患者血清肿瘤坏死因子(TNF-α)和白细胞介素-6(IL-6)水平的变化及临床意义。方法:采用放射免疫分析对55例老年慢性支气管哮喘患者进行了血清TNF-α和IL-6水平检测,并以35名正常健康人作比较。结果:老年慢性支气管哮喘患者血清TNF-α和IL-6水平非常显著地高于正常人组(P<0.01),经治疗2周后则与正常人比较无显著性差异(P>0.05)。结论:血清TNF-α和IL-6异常的升高是老年支气管哮喘发病的病理因素之一,有重要的临床意义。

Objective To explore the clinical significance of changes of serum TNF -α and IL - 6 levels in eldery patients with chronic bronchial asthma. Methods Serum TNF -α and IL - 6 levels were determined with RIA in 55 elderly patients with chronic bronchial asthma and 35 controls. Results Serum TNF - α and IL - 6 levels were significantly higher in the patients than those in controis （P 〈0.01 ）. After treatment two weeks there were no significant differences between the levels in these two groups （P 〉 0.05）. Conclusion Abnormal high serum TNF - α and IL - 6 levels were important pathophysiologic features in chronic bronchial asthma.